Necrostatin-1 | Inhibits necroptosis

CAS:
4311-88-0
Catalog Number:
10-1162
Activity:
Inhibits necroptosis
Chemical Name:
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone
Molecular Weight:
259.33
Molecular Formula:
C13H13N3OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied.  Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
10 mg$55.00
50 mg$165.00

Necrostatin-1 (4311-88-0) is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 Necrostatin-1 displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4.

References/Citations:

1) Degterev, et al. (2005), Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury‘ Nature Chem. Biol., 1 112
2) Degterev et al. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins; Nature Chem. Biol., 4 313
3) Smith et.al. (2007), Necrostatin: a potentially novel cardioprotective agent?; Cardiovasc. Drugs Ther., 21 227
4) Xu et.al. (2007), Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells; J. Neurochem., 103 2004

CAS:
4311-88-0
Catalog Number:
10-1162
Activity:
Inhibits necroptosis
Chemical Name:
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone
Molecular Weight:
259.33
Molecular Formula:
C13H13N3OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied.  Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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