Necrostatin-34 | RIP1 kinase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $90.00 | ||
| 25 mg | $285.00 |
Necrostatin-34 (375835-43-1) is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.
References/Citations:
- Meng et al. (2021), Discovery of a cooperative mode of inhibiting RIPK1 kinase; Cell Discov. 7 41
C18H16N4O2S2
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Necrostatin-34 (375835-43-1) is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.
References/Citations:
- Meng et al. (2021), Discovery of a cooperative mode of inhibiting RIPK1 kinase; Cell Discov. 7 41
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