FOCUS on Reversal of Tau Pathology. In a January Communications Biology paper, Eric McGregor and coworkers showed that adiponectin receptor activation with the small molecule agonist, AdipoRon, cleared neurofibrillary tangles (NFTs) and rescued neuronal tauopathy-associated defects. AdipoRon reduced levels of phospho-tau and lowered NFT burden via a mechanism involving the energy-sensing kinase AMPK and the growth-sensing kinase GSK3beta. The negative effects of NFTs on mitochondrial activity, ATP production, and lipid stores were corrected, revealing a network linking mitochondrial function and cellular maintenance processes that can be targeted via adiponectin receptors. The BBB permeability of AdipoRon is noteworthy.
Focus Biomolecules can supply Adiporon for research applications.
Website Created by Advanta Advertising LLC.
