FOCUS on Reversal of Tau Pathology. In a January Communications Biology paper, Eric McGregor and coworkers showed that adiponectin receptor activation with the small molecule agonist, AdipoRon, cleared neurofibrillary tangles (NFTs) and rescued neuronal tauopathy-associated defects. AdipoRon reduced levels of phospho-tau and lowered NFT burden via a mechanism involving the energy-sensing kinase AMPK and the growth-sensing kinase GSK3beta. The negative effects of NFTs on mitochondrial activity, ATP production, and lipid stores were corrected, revealing a network linking mitochondrial function and cellular maintenance processes that can be targeted via adiponectin receptors. The BBB permeability of AdipoRon is noteworthy.
Focus Biomolecules can supply Adiporon for research applications.
