SB-225002 | CXCR2 antagonist

CAS:
182498-32-4
Catalog Number:
10-2850
Activity:
CXCR2 antagonist
Chemical Name:
N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
Molecular Weight:
352.14
Molecular Formula:
C13H10BrN3O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$60.00
25 mg$240.00

SB-225002 (CAS 182498-32-4) is a potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors.1 Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe.2   Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence3 and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages.4  Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation.5

References/Citations:

1) White et al. (1998), Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration; J. Biol. Chem. 273 10095
2) Du et al. (2013) SB225002 Promotes Mitotic Catastrophe in Chemo-Sensitive and -Resistant Ovarian Cancer Cells Independent of p53 Status In Vitro; PLoS One. 8 e54572
3) Shen et al. (2013), Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation; Int. Immunopharmacol. 16 261
4) Lane et al. (2001), Interleukin-8 Stimulates Human Immunodeficiency Virus Type 1 Replication and Is a Potential New target for Antiretroviral Therapy; J. Virol. 75 8195
5) Wu et al. (2015), CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation; J. Neuroinflammation 12 98

CAS:
182498-32-4
Catalog Number:
10-2850
Activity:
CXCR2 antagonist
Chemical Name:
N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
Molecular Weight:
352.14
Molecular Formula:
C13H10BrN3O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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