Ganetespib | HSP90 inhibitor

Ganetespib (888216-25-9) is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site.It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors  with IC50’s between 14 and 280 nM.2 Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes.3 In multiple clinical trials for various cancers.

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References/Citations for Ganetespib

  1. Lin et al. (2008), The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors; Exp. Hematol. 36 1266
  2. Ying et al. (2012), Ganetespib, a Unique Triazoline-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy; Mol. Cancer Ther. 11 475
  3. Mbofung et al. (2017), HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes; Nat. Commun. 8 451
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

5 mg, 25 mg

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CAS:
888216-25-9
Catalog Number:
10-4474
Activity:
HSP90 inhibitor
Chemical Name:

3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one;

Molecular Weight:
364.40
Molecular Formula:
C20H20N4O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Ganetespib | HSP90 inhibitor

$65.00$250.00

CAS:
888216-25-9
Catalog Number:
10-4474
Activity:
HSP90 inhibitor
Chemical Name:

3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one;

Molecular Weight:
364.40
Molecular Formula:
C20H20N4O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
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