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Norfluoxetine HCl | Fluoxetine Metabolite

Norfluoxetine HCl (57226-68-3) is a metabolite of fluoxetine.3 Induces long QT syndrome via slow delayed rectifier potassium current block.1 Time dependent inhibitor of CYP2C19 and CYP3A4.2   The S-isomer of desmethylfluoxetine is the active N-demethylated metabolite responsible for the persistently potent and selective inhibition of serotonin uptake in vivo.3 Potent inhibitor of coxsackievirus replication acting via inhibition of viral RNA synthesis.4 State-dependent TREK-2 blocker.5


1) Veerman et al. (2013), Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome; Circ. Arrythm. Electrophysiol. 6 1002
2) Lutz et al. (2013), Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems; Drug Metab. Dispos. 41 2056
3) Wong et al. (1993), Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain; Neuropsychopharmacology 8 337
4) Zuo et al. (2012), Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob. Agents Chemother. 56 4838
5) McClenaghan et al. (2016), Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J. Gen. Physiol. 147 497

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Catalog#  10-2671-0005

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Catalog Number:
Alternate Name:
Fluuxetine metabolite
Chemical Name:
3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride (racemic)
Molecular Weight:
Molecular Formula:
C16H16F3NO HCl
Soluble in DMSO ( up to at least 25 mg/ml)
Physical Properties:
Beige waxy solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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