Glumetinib | Highly selective c-Met inhibitor

Glumetinib (1642581-63-2) is a highly selective (2400-fold selectivity against a panel of 312 kinases) and potent (IC50 = 0.42 nM) inhibitor of c-Met kinase.  It induced tumor regression in MET-driven CDX (MKN-45, SNU-5, EBC-1) and PDX (4 NSCLC, 5 HCC) tumor models.

  1. Ai et al. (2018), Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models; Cancer Res., 17 751
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
1642581-63-2
Catalog Number:
10-4690
Activity:
Highly selective c-Met inhibitor
Chemical Names:
6-(1-Methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridine-3-yl]sulfonylpyrazolo[4,3-b]pyridine: SCC244
Molecular Weight:
459.48
Molecular Formula:
C21H17N9O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Glumetinib | Highly selective c-Met inhibitor

$90.00$325.00

CAS:
1642581-63-2
Catalog Number:
10-4690
Activity:
Highly selective c-Met inhibitor
Chemical Names:
6-(1-Methylpyrazol-4-yl)-1-[6-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridine-3-yl]sulfonylpyrazolo[4,3-b]pyridine: SCC244
Molecular Weight:
459.48
Molecular Formula:
C21H17N9O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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