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Product Details

MitoBloCK-12 | Mitochondrial import inhibitor

MitoBloCK-12 (522-51-0) attenuates mitochondrial protein import (4-10 μM). Discovered in a screen of FDA-approved drugs. Blocks translocation of a mutant form of alanine: glyoxylate aminotransferase (AGT) to the mitochondria and restores AGT trafficking to peroxisomes.1 Also reduces oxalate accumulation and thus has potential to treat patients with primary hyperoxaluria 1 who possess mutations in AGT.1 Also displays antimicrobial activity2, inhibits apamin-sensitive K+ channels3 and induces apoptosis by inhibiting XIAP4.

References/Citations
1) Miyata et al. (2014), Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1; Proc. Natl. Acad. Sci. USA 111 14406
2) Frey Tirri et al. (2011), Antimicrobial topical agents used in the vagina; Curr. Probl. Dermatol. 40 36
3) Castle et al. (1993), Dequalinium: a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle; Eur. J. Pharmacol. 236 201
4) Orzaez et al. (2011), Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain; Apoptosis 16 460

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Catalog#  10-1525-0050

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
522-51-0
Catalog Number:
10-1525
Activity:
Mitochondrial import inhibitor
Chemical Name:
1,1’-Decamethylenebis(4-aminoquinaldinium)dichloride
Alternate Name:
Dequalinium chloride; MB12; DECA
Molecular Weight:
527.58
Molecular Formula:
C30H40Cl2N4
Solubility:
Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 1 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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