SKA-31 | Potassium channel activator

SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3

References:

  1. Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Pharmacol., 75 281
  2. Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323
  3. Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; J. Pharnacol., 831 60
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

10 mg, 50 mg

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CAS:
40172-65-4
Catalog Number:
10-5483
Activity:
Potassium channel activator
Chemical Names:
Naphtho[1,2-d]thiazol-2-ylamine; 2-Aminonapthiazole
Molecular Weight:
200.25
Molecular Formula:
C11H8N2S
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

SKA-31 | Potassium channel activator

$60.00$200.00

CAS:
40172-65-4
Catalog Number:
10-5483
Activity:
Potassium channel activator
Chemical Names:
Naphtho[1,2-d]thiazol-2-ylamine; 2-Aminonapthiazole
Molecular Weight:
200.25
Molecular Formula:
C11H8N2S
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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