TTNPB | Retinoid RAR agonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $66.00 | ||
| 25 mg | $220.00 |
TTNPB is a highly potent and selective retinoic acid analog acting as an RAR agonist (EC50 = 21, 4 and 2.4 nM for RARα, RARβ and RARγ respectively).1 TTNPB has been extensively used in stem cell differentiation protocols. It enhances reprogramming efficiency in chemically induced pluripotent stem cells.2 Chondrocytes are robustly induced from human pluripotent stem cells by treatment with CHIR99021 and TTNPB.3 TTNPB alone, efficiently converts primary adult mouse fibroblasts into dermal papilla cell-like cells.4 Can be used in combination with other small molecules for induction of mouse totipotent stem cells.5
References/Citations:
- Beard et al. (1995), Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids; J. Med. Chem., 38 2820
- Hou et al. (2013), Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds; Science, 341 651
- Kawata et al. (2019), Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds; Stem Cell Reports, 13 530
- Ma et al. (2022), Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules; Int. J. Mol. Sci., 23 4213
- Hu et al. (2022), Induction of mouse totipotent stem cells by a defined chemical cocktail; Nature, Online ahead of print
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TTNPB is a highly potent and selective retinoic acid analog acting as an RAR agonist (EC50 = 21, 4 and 2.4 nM for RARα, RARβ and RARγ respectively).1 TTNPB has been extensively used in stem cell differentiation protocols. It enhances reprogramming efficiency in chemically induced pluripotent stem cells.2 Chondrocytes are robustly induced from human pluripotent stem cells by treatment with CHIR99021 and TTNPB.3 TTNPB alone, efficiently converts primary adult mouse fibroblasts into dermal papilla cell-like cells.4 Can be used in combination with other small molecules for induction of mouse totipotent stem cells.5
References/Citations:
- Beard et al. (1995), Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids; J. Med. Chem., 38 2820
- Hou et al. (2013), Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds; Science, 341 651
- Kawata et al. (2019), Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds; Stem Cell Reports, 13 530
- Ma et al. (2022), Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules; Int. J. Mol. Sci., 23 4213
- Hu et al. (2022), Induction of mouse totipotent stem cells by a defined chemical cocktail; Nature, Online ahead of print
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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