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N-Eicosanoyl serotonin | Neuroprotective

N-eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy1. It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance.  It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease2,3.

1) Yan et al. (2018), Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB; Proc. Natl. Acad. Sci. USA, 115 E12053
2) Asam et al. (2017), Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid; PLoS One, 12 e0189413
3) Basurto-Islas et al. (2014), Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease; Neurobiol. Aging, 35 2701

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Catalog#  10-3631-0010

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Catalog Number:
Chemical Name:
Alternate Name:
Eicosanoyl serotonin, EHT
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Physical Properties:
Beige solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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