Yan and coworkers have demonstrated a potential way to boost innate immune attack on solid tumors. They found that Rocaglamide, a structurally novel natural product, promoted
Mitapivat is an allosteric activator of red blood cell pyruvate kinase, the enzyme that performs the final step of glycolysis: it catalyzes the conversion of phosphoenolpyruvate
Cancer cells modify their metabolism in order to survive and grow. For example, they employ the Warburg effect (increasing glucose uptake and directly converting it to
Lipid raft dynamics regulate signaling for multiple cellular functions, such as apoptosis, proliferation, and differentiation. They reside in the plasma membrane and comprise sphingolipids, cholesterol, and
Kumar et al. and Zijlmans et al. have published in Nature Cell Biology that Polycomb repressive complex 2 (PRC2) epigenetically reduces lineage potential of hESCs. They
JTE-607, a cell-permeable prodrug which is converted to its active COOH form via intracellular esterases, was originally found to inhibit cytokine release but its mechanism of
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