Carlos Guijas and coworkers at Scripps recently found that the leukotriene antagonist and antiasthmatic agent zafirlukast was able to differentiate adipocyte precursors into functional brown adipocytes.
Yuki Yoshimatsu and coworkers have shown that they could establish patient-derived cancer cell lines for myxofibrosarcoma and pleomorphic sarcoma. After screening these cell lines with a
P. Hiengrach and coworkers recently showed that BAM15, a mitochondrial uncoupling agent, attenuated sepsis in a mouse cecal ligation and puncture model. BAM15 attenuated sepsis as
Activation of autophagy is a novel mode of therapeutic intervention and offers the possibility of developing new “host-directed” therapeutics against mycobacterial infection. For example, Kim et
Paula Juricic and coworkers at the Max Planck Institute for Biology of Ageing report in a recent issue of Nature Aging that a brief early treatment
Robert Prior and coworkers report in a recent issue of Molecular Neurobiology that inhibition of HDAC3 with RGFP966, a highly selective HDAC3 inhibitor, stimulates myelination in
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