In a recent paper in Cell Research, Li and coworkers explored the nuclear function of RIPK1 and demonstrated that RIPK1 phosphorylates a key component of the
In the August issue of J. Antibiotics (Tokyo) Yoshida and coworkers at the University of Tsukuba reviewed their excellent work on synthesis, SAR, biology and chemical
Yan and coworkers have demonstrated a potential way to boost innate immune attack on solid tumors. They found that Rocaglamide, a structurally novel natural product, promoted
Mitapivat is an allosteric activator of red blood cell pyruvate kinase, the enzyme that performs the final step of glycolysis: it catalyzes the conversion of phosphoenolpyruvate
Cancer cells modify their metabolism in order to survive and grow. For example, they employ the Warburg effect (increasing glucose uptake and directly converting it to
Lipid raft dynamics regulate signaling for multiple cellular functions, such as apoptosis, proliferation, and differentiation. They reside in the plasma membrane and comprise sphingolipids, cholesterol, and
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