NG-497 | Human ATGL inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $260.00 |
NG-497 (2598242-66-9) is the first small molecule inhibitor (IC50 = 1 µM) of human (and rhesus monkey) adipose triglyceride lipase (ATGL). It is inactive against mouse, rat, goat, pig, dog, and marmoset ATGL orthologues. Of the eight enzymes expressed by humans in the patatin-like phospholipase domain-containing (PNPLA) protein family, NG-497 was selective for PNPLA 2 (ATGL is PNPLA2). NG-497 was also inactive against HSL, CES2, LPL, and HL. Reversible and non-toxic.
References/Citations:
- Grabner et al. (2022), Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes; J. Am. Chem. Soc. 144 6237
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NG-497 (2598242-66-9) is the first small molecule inhibitor (IC50 = 1 µM) of human (and rhesus monkey) adipose triglyceride lipase (ATGL). It is inactive against mouse, rat, goat, pig, dog, and marmoset ATGL orthologues. Of the eight enzymes expressed by humans in the patatin-like phospholipase domain-containing (PNPLA) protein family, NG-497 was selective for PNPLA 2 (ATGL is PNPLA2). NG-497 was also inactive against HSL, CES2, LPL, and HL. Reversible and non-toxic.
References/Citations:
- Grabner et al. (2022), Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes; J. Am. Chem. Soc. 144 6237
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1-855-FOCUS21
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