NG52 | Phosphoglycerate kinase 1 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $295.00 |
NG52 (212779-48-1) is an inhibitor of Cdc2-cyclin B (IC50 = 340 nM) as well as Cdc28p (IC50 = 7 µM) and Pho85p (IC50 = 2 µM).1 It inhibited phosphoglycerate kinase 1 (IC50 = 2.5 µM) and inhibited the proliferation of glioma U87 and U251 cell lines via reversal of the Warburg effect.2 NG52 inhibited the proliferation, increased apoptosis, and reduced the migration and invasive ability of OVCAR3 and ES-2 ovarian cancer cell lines via suppression of glycolytic capability.3
References/Citations:
- Gray et al. (1998), Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors; Science, 281 533
- Wang et al. (2021), Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52; Acta Pharmacol. Sin., 42 633
- Gou et al. (2021), PGK1 Is a Key Target for Anti-Glycolytic Therapy of Ovarian Cancer: Based on the Comprehensive Analysis of Glycolysis-Related Genes; Front. Oncol., 11 682461
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NG52 (212779-48-1) is an inhibitor of Cdc2-cyclin B (IC50 = 340 nM) as well as Cdc28p (IC50 = 7 µM) and Pho85p (IC50 = 2 µM).1 It inhibited phosphoglycerate kinase 1 (IC50 = 2.5 µM) and inhibited the proliferation of glioma U87 and U251 cell lines via reversal of the Warburg effect.2 NG52 inhibited the proliferation, increased apoptosis, and reduced the migration and invasive ability of OVCAR3 and ES-2 ovarian cancer cell lines via suppression of glycolytic capability.3
References/Citations:
- Gray et al. (1998), Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors; Science, 281 533
- Wang et al. (2021), Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52; Acta Pharmacol. Sin., 42 633
- Gou et al. (2021), PGK1 Is a Key Target for Anti-Glycolytic Therapy of Ovarian Cancer: Based on the Comprehensive Analysis of Glycolysis-Related Genes; Front. Oncol., 11 682461
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