Nicotinamide | SIRT1 inhibitor/essential nutrient
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 g | $20.00 | ||
| 5 g | $40.00 |
Nicotinamide (98-92-0) is an essential nutrient (amide form of Vitamin B3) that is incorporated into cofactors NADH/NAD+, important for ATP production and other key metabolic functions.1 Transiently inhibits SIRT1/SIRT3 through feedback inhibition (IC50 ~ 50 µM)2, but is quickly converted to NAD+ in cells3. Also inhibits certain kinases (e.g. ROCK and CK1), making it a regulator of hPSC pluripotency, survival, and differentiation.4 Inhibits differentiation and enhances functionality of hematopoietic stem/progenitor cells (HSPCs).5
References/Citations:
- Zapata-Pérez et al. (2021), NAD+ homeostasis in human health and disease; EMBO Mol. Med., 13 e13943
- Guan et al. (2014), Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies; PLoS One, 9 e107729
- Hwang and Song (2017), Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells; Mol. Life Sci., 74 3347
- Meng et al. (2018), Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells; Stem Cell Reports, 11 1347
- Horwitz et al. (2014), Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment; Clin. Invest., 124 3121
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Nicotinamide (98-92-0) is an essential nutrient (amide form of Vitamin B3) that is incorporated into cofactors NADH/NAD+, important for ATP production and other key metabolic functions.1 Transiently inhibits SIRT1/SIRT3 through feedback inhibition (IC50 ~ 50 µM)2, but is quickly converted to NAD+ in cells3. Also inhibits certain kinases (e.g. ROCK and CK1), making it a regulator of hPSC pluripotency, survival, and differentiation.4 Inhibits differentiation and enhances functionality of hematopoietic stem/progenitor cells (HSPCs).5
References/Citations:
- Zapata-Pérez et al. (2021), NAD+ homeostasis in human health and disease; EMBO Mol. Med., 13 e13943
- Guan et al. (2014), Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies; PLoS One, 9 e107729
- Hwang and Song (2017), Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells; Mol. Life Sci., 74 3347
- Meng et al. (2018), Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells; Stem Cell Reports, 11 1347
- Horwitz et al. (2014), Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment; Clin. Invest., 124 3121
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