Nilvadipine | Syk inhibitor/Calcium channel blocker
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 50 mg | $70.00 | ||
| 250 mg | $250.00 |
Nilvadipine (75530-68-6) is a novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model.1 Clinically useful antihypertensive agent.2 Has been shown to prevent cognitive decline in some clinical trials.3 Nilvadipine produces a protective effect on glutamate neurotoxicity in retinal ganglion cells, an effect not shared by other L-type Ca2+ channel blockers such as nifedipine and diltiazem.4
References/Citations:
1) Paris et al. (2014), The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation; J. Biol. Chem., 289 33927
2) Rosenthal (1994), Nilvadipine: profile of a new calcium antagonist. An overview; J. Cardiovasc. Pharmacol. 24 Suppl 2 S92
3) Nimmrich and Eckert (2013), Calcium channel blockers and dementia; Br. J. Pharmacol. 169 1203
4) Otori et al. (2003), Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells; Brain Res. 961 213
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Nilvadipine (75530-68-6) is a novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model.1 Clinically useful antihypertensive agent.2 Has been shown to prevent cognitive decline in some clinical trials.3 Nilvadipine produces a protective effect on glutamate neurotoxicity in retinal ganglion cells, an effect not shared by other L-type Ca2+ channel blockers such as nifedipine and diltiazem.4
References/Citations:
1) Paris et al. (2014), The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation; J. Biol. Chem., 289 33927
2) Rosenthal (1994), Nilvadipine: profile of a new calcium antagonist. An overview; J. Cardiovasc. Pharmacol. 24 Suppl 2 S92
3) Nimmrich and Eckert (2013), Calcium channel blockers and dementia; Br. J. Pharmacol. 169 1203
4) Otori et al. (2003), Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells; Brain Res. 961 213
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