Nintedanib | VEGFR, PDGFR, and FGFR kinase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $45.00 | ||
| 50 mg | $100.00 |
Nintedanib (656247-17-5) is a potent inhibitor of VEGFR, PDGFR, FGFR (IC50 = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes).1 Also inhibits Flt-3, Lck, Lyn and Src (IC50 = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs.1 Inhibits tumor growth in a mouse tumor xenograft model.1 A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis.2,3 Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.4
References/Citations:
- Hilberg et al. (2008), BIBF-1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy; Cancer Res. 68 4774
- Dimitroulis et al. (2014), Nintedanib: a novel therapeutic approach for idiopathic pulmonary fibrosis; Respir. Care 59 1450
- Guo et al. (2023), Progress in understanding and treating idiopathic pulmonary fibrosis: recent insights and emerging therapies; Front. Pharmacol. 14 1205948
- Han et al. (2023), Nintedanib Alleviates Chronic Pancreatitis by Inhibiting the Activation of Pancreatic Stellate Cells via the JAK/STAT3 and ERK1/2 Pathways; Dig. Dis. Sci. 68 3644
C31H33N5O4
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Nintedanib (656247-17-5) is a potent inhibitor of VEGFR, PDGFR, FGFR (IC50 = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes).1 Also inhibits Flt-3, Lck, Lyn and Src (IC50 = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs.1 Inhibits tumor growth in a mouse tumor xenograft model.1 A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis.2,3 Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.4
References/Citations:
- Hilberg et al. (2008), BIBF-1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy; Cancer Res. 68 4774
- Dimitroulis et al. (2014), Nintedanib: a novel therapeutic approach for idiopathic pulmonary fibrosis; Respir. Care 59 1450
- Guo et al. (2023), Progress in understanding and treating idiopathic pulmonary fibrosis: recent insights and emerging therapies; Front. Pharmacol. 14 1205948
- Han et al. (2023), Nintedanib Alleviates Chronic Pancreatitis by Inhibiting the Activation of Pancreatic Stellate Cells via the JAK/STAT3 and ERK1/2 Pathways; Dig. Dis. Sci. 68 3644
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