N,N-Dimethylsphingosine | Inhibits sphingosine kinase

CAS:
119567-63-4
Catalog Number:
10-2285
Activity:
Inhibits sphingosine kinase
Chemical Name:
(2S,3R,E)-2-(Dimethylamino)octadeca-4-ene-1,3-diol
Molecular Weight:
327.56
Molecular Formula:
C20H41NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid or viscous oil
Purity:
98% by TLC
NMR (Conforrms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$57.00
25 mg$228.00

N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1 Inhibits sphingosine kinase (IC50 = 5 μM).2 N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3

References/Citations:

1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385
2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626
3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal; FASEB J., 22 2629

CAS:
119567-63-4
Catalog Number:
10-2285
Activity:
Inhibits sphingosine kinase
Chemical Name:
(2S,3R,E)-2-(Dimethylamino)octadeca-4-ene-1,3-diol
Molecular Weight:
327.56
Molecular Formula:
C20H41NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid or viscous oil
Purity:
98% by TLC
NMR (Conforrms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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