N,N-Dimethylsphingosine | Inhibits sphingosine kinase
NMR (Conforrms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $57.00 | ||
| 25 mg | $228.00 |
N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1 Inhibits sphingosine kinase (IC50 = 5 μM).2 N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3
References/Citations:
1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385
2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626
3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal; FASEB J., 22 2629
NMR (Conforrms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1 Inhibits sphingosine kinase (IC50 = 5 μM).2 N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3
References/Citations:
1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385
2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626
3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal; FASEB J., 22 2629
Related products
-
EPA free acid | omega-3 fatty acid
From $30.00CAS:10417-94-4Catalog Number:10-1313Activity:omega-3 fatty acidAlternate Names:Eicosapentaenoic acidChemical Name:Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic acid (20:5, n-3)Molecular Weight:302.46Molecular Formula:C20H30O2Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 100 mg/ml).Physical Properties:Colorless to pale yellow oilPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied (unopened). After opening, EPA must be stored under inert gas at -80°C. Solutions in DMSO or ethanol should also be stored under inert gas and may be kept at -80°C for up to 2 months.Shipping Code:RT -
Ginkgolide B | PAF receptor antagonist
From $40.00CAS:15291-77-7Catalog Number:10-1080Activity:PAF antagonistAlternate Names:BN 52021Chemical Name:Natural product isolated from Ginko bilobaMolecular Weight:424.41Molecular Formula:C20H24O10Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 monthsShipping Code:RT -
Lovastatin | HMG-CoA reductase inhibitor
From $50.00CAS:75330-75-5Catalog Number:10-1222Activity:HMG-CoA reductase inhibitorAlternate Names:MevinolinChemical Name:2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acidMolecular Weight:404.55Molecular Formula:C24H36O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
