Nobiletin | Attenuates metabolic syndrome
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $45.00 | ||
| 50 mg | $135.00 |
Nobiletin (478-01-3) is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
References/Citations:
1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610
2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446
3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814
4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683
5) Walle (2007), Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass?; Semin. Cancer Biol. 17 354
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Nobiletin (478-01-3) is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
References/Citations:
1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610
2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446
3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814
4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683
5) Walle (2007), Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass?; Semin. Cancer Biol. 17 354
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