Nobiletin | Attenuates metabolic syndrome
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $45.00 | ||
| 50 mg | $135.00 |
Nobiletin (478-01-3) is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
References/Citations:
1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610
2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446
3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814
4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683
5) Walle (2007), Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass?; Semin. Cancer Biol. 17 354
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Nobiletin (478-01-3) is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
References/Citations:
1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610
2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446
3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814
4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683
5) Walle (2007), Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass?; Semin. Cancer Biol. 17 354
Related products
-
SR-9009 | RevErb alpha/beta agonist
From $70.00CAS:1379686-30-2Catalog Number:10-1511Activity:RevErbα/β agonistChemical Name:Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochlorideMolecular Weight:474.4Molecular Formula:C20H24CLN3O4S HClSolubility:Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:Tan solidPurity:98% by TLCStorage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
GW-9508 | GPR40 agonist
From $65.00CAS:885101-89-3Catalog Number:10-1108Activity:GPR40 agonistChemical Name:4-(3-Phenoxybenzylamino)phenylpropionic acidMolecular Weight:347.42Molecular Formula:C22H21NO3Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Off-white solidPurity:>98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Rosiglitazone maleate | PPAR gamma agonist
From $55.00CAS:155141-29-0Catalog Number:10-1012Activity:PPARγ agonistAlternate Names:Avandia; BRL49653Chemical Name:5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleateMolecular Weight:357.43Molecular Formula:C18H19N3O3SSolubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 monthsShipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
