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Nobiletin | Attenuates metabolic syndrome

Nobiletin (478-01-3) is a natural product isolated from citrus peels.  It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1  Nobiletin directly bound to and activated RORα/γ.  Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.

References/Citations

1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610
2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446
3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814
4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683
5) Walle (2007), Methoxylated flavones,a superior cancer chemopreventative flavonoid subclass?; Semin. Cancer Biol. 17 354

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Catalog#  10-4763-0010

$50.00
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CAS:
478-01-3
Catalog Number:
10-4763
Activity:
Attenuates metabolic syndrome
Chemical Name:
3’,4’,5,6,7,8-Hexamethoxyflavone
Molecular Weight:
402.39
Molecular Formula:
C21H22O8
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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