Nobiletin (478-01-3) is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610
2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446
3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814
4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683
5) Walle (2007), Methoxylated flavones,a superior cancer chemopreventative flavonoid subclass?; Semin. Cancer Biol. 17 354