Nocardamine | Iron chelator/Ferroptosis inhibitor
CAS:
26605-16-3
Catalog Number:
10-2775
Activity:
Iron chelator/Ferroptosis inhibitor
Chemical Names:
1,12,23-Trihydroxy-1,6,12,17,23,28-hexazacyclotritriacontane-2,5,13,16,24,27-hexone
Alternate Name:
Desferrioxamine E
Molecular Weight:
600.71
Molecular Formula:
C27H48N6O9
Solubility:
Soluble in DMSO (5 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Nocardamine (26605-16-3) is a bacterially produced siderophore1 which can act as an intracellular ion chelator2. A cyclic analog of the ferroptosis inhibiting siderophore desferoxamine.3 Displayed inhibitory effects to colony formation of T-47D, SK-Mel-5, SK-Mel-28 and PRMI-7951 tumor cell lines4 as well as antimalarial activity5.
References/Citations:
- Normant et al. (2020), Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter; ACS Chem. Biol. 15 2741
- Ueki et al. (2009), Nocardamin Production by Streptomyces avermitilis; Actinomycetologica 23 34
- Yan et al. (2021), Ferroptosis: mechanisms and links with diseases; Signal Transduct. Target Ther. 6 49
- Kalinovskaya et al. (2011), Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity; Res. 166 654
- Mahmud et al. (2022), Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809; Molecules 27 2292
CAS:
26605-16-3
Catalog Number:
10-2775
Activity:
Iron chelator/Ferroptosis inhibitor
Chemical Names:
1,12,23-Trihydroxy-1,6,12,17,23,28-hexazacyclotritriacontane-2,5,13,16,24,27-hexone
Alternate Name:
Desferrioxamine E
Molecular Weight:
600.71
Molecular Formula:
C27H48N6O9
Solubility:
Soluble in DMSO (5 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Nocardamine (26605-16-3) is a bacterially produced siderophore1 which can act as an intracellular ion chelator2. A cyclic analog of the ferroptosis inhibiting siderophore desferoxamine.3 Displayed inhibitory effects to colony formation of T-47D, SK-Mel-5, SK-Mel-28 and PRMI-7951 tumor cell lines4 as well as antimalarial activity5.
References/Citations:
- Normant et al. (2020), Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter; ACS Chem. Biol. 15 2741
- Ueki et al. (2009), Nocardamin Production by Streptomyces avermitilis; Actinomycetologica 23 34
- Yan et al. (2021), Ferroptosis: mechanisms and links with diseases; Signal Transduct. Target Ther. 6 49
- Kalinovskaya et al. (2011), Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity; Res. 166 654
- Mahmud et al. (2022), Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809; Molecules 27 2292
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