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Product Details

Nocodazole | Microtubule inhibitor

Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex1,2. Arrests cell cycle at G2/M phase. Stimulates the intrinsic GTPase activity of tubulin3. Nocodazole activates the JNK/SAPK signaling pathway and induces apoptosis in a variety of cell lines4. Cell permeable.

References/Citations
1) Jordan et al. (1992), Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis; J. Cell Science, 102 401
2) Storrie et al. (1998), Dynamics of the interphase mammalian Golgi complex as revealed through drugs producing reversible Golgi disassembly; Biochim. Biophys. Acta, 1404 127
3) Mejillano et al. (1996), Studies on the nocodazole-induced GTPase activity of tubulin; Arch. Biochem. Biophys., 336 130
4) Wang et al. (1998), Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways; J. Biol. Chem., 273 4928

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Catalog#  10-2387-0010

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
31430-18-9
Catalog Number:
10-2387
Activity:
Microtubule inhibitor
Alternate Names:
R-17934
Chemical Name:
Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
Molecular Weight:
301.32
Molecular Formula:
C14H11N3O3S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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