NPC-15437 | PKC inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $56.00 | ||
| 5 mg | $220.00 |
NPC-15437 (141774-20-1) is a potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19 µM).1,2 It specifically interacts with the C1 domain of PKC.3 Important tool for assessing the role of PKC in various signaling pathways.4 Cell permeable. Active in vivo.4
References/Citations
1) Sullivan et al. (1992), 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain; Mol. Pharmacol., 41 38
2) Sullivan et al. (1991), 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C; Agents Actions 34 142
3) Sullivan et al. (1991), NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs; FEBS Lett., 285 120
4) Miyoshi et al. (2007), mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption; Eur. J. Pharmacol., 562 208
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NPC-15437 (141774-20-1) is a potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19 µM).1,2 It specifically interacts with the C1 domain of PKC.3 Important tool for assessing the role of PKC in various signaling pathways.4 Cell permeable. Active in vivo.4
References/Citations
1) Sullivan et al. (1992), 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain; Mol. Pharmacol., 41 38
2) Sullivan et al. (1991), 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C; Agents Actions 34 142
3) Sullivan et al. (1991), NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs; FEBS Lett., 285 120
4) Miyoshi et al. (2007), mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption; Eur. J. Pharmacol., 562 208
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