NR2E3 agonist 11a | NR2E3 agonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $100.00 | ||
| 25 mg | $375.00 |
11a (911211-69-3) is an agonist of the photoreceptor-specific nuclear receptor (NR2E3; PNR; RNR), found in rod photoreceptor cells (EC50 = 141 nM ß-lactamase assay; 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3
References/Citations:
- Wolkenberg et al. (2006), Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand; Bioorg. Med. Chem. Lett., 16 5001
- Wang et al. (2025), Orphan nuclear receptor NR2E3 is a new molecular vulnerability in solid tumors by activating p53; Cell Death Dis., 16 15
- Zhao et al. (2013), Systematic Analyses of the Cytotoxic Effects of Compound 11a, a Putative Synthetic Agonist of Photoreceptor-Specific Nuclear Receptor (PNR), in Cancer Cell Lines; PLoS One, 8 e75198
C24H19ClN4O2
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
11a (911211-69-3) is an agonist of the photoreceptor-specific nuclear receptor (NR2E3; PNR; RNR), found in rod photoreceptor cells (EC50 = 141 nM ß-lactamase assay; 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3
References/Citations:
- Wolkenberg et al. (2006), Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand; Bioorg. Med. Chem. Lett., 16 5001
- Wang et al. (2025), Orphan nuclear receptor NR2E3 is a new molecular vulnerability in solid tumors by activating p53; Cell Death Dis., 16 15
- Zhao et al. (2013), Systematic Analyses of the Cytotoxic Effects of Compound 11a, a Putative Synthetic Agonist of Photoreceptor-Specific Nuclear Receptor (PNR), in Cancer Cell Lines; PLoS One, 8 e75198
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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