NS 1619 | Selective KCa1.1 activator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $215.00 |
NS 1619 (153587-10-0) is a selective activator of large conductance Ca(2+)-dependent potassium channels (BKCa or KCa1.1).1,2 It was able to increase blood-brain tumor barrier permeability in rat brain tumor models.3,4 NS 1619 inhibited proliferation and induced apoptosis in A2780 ovarian cancer cells.5 Displays cardioprotective effects in an ischemia-reperfusion model6 and neuroprotective effects in a traumatic brain injury model7.
References/Citations:
- Olesen et al. (1994), Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone; Eur. J. Pharmacol. 251 53
- Sellers and Ashford (1994), Activation of BKCa channels in acutely dissociated neurons from the rat ventromedial hypothalamus by NS 1619; Br. J. Pharmacol. 113 659
- Ningaraj et al. (2002), Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels; J. Pharmacol. Exp. Ther. 301 838
- Ningaraj et al. (2009), Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model; Cancer Biol. Ther. 8 1924
- Han et al. (2008), The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells; Biochem. Biophys. Res. Commun. 375 205
- Dai et al. (2017), Preconditioning with the BKCa channel activator NS-1619 prevents ischemia-reperfusion-induced inflammation and mucosal barrier dysfunction: roles for ROS and heme oxygenase-1; Am. J. Physiol. Heart Circ. Physiol. 313 H988
- Gao et al. (2022), NS1619 Alleviate Brain-Derived Extracellular Vesicle-Induced Brain Injury by Regulating BKCa Channel and Nrf2/HO-1/NK-kB Pathway; Oxid. Med. Cell Longev. 2022 2257427
C15H8F6N2O2
98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NS 1619 (153587-10-0) is a selective activator of large conductance Ca(2+)-dependent potassium channels (BKCa or KCa1.1).1,2 It was able to increase blood-brain tumor barrier permeability in rat brain tumor models.3,4 NS 1619 inhibited proliferation and induced apoptosis in A2780 ovarian cancer cells.5 Displays cardioprotective effects in an ischemia-reperfusion model6 and neuroprotective effects in a traumatic brain injury model7.
References/Citations:
- Olesen et al. (1994), Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone; Eur. J. Pharmacol. 251 53
- Sellers and Ashford (1994), Activation of BKCa channels in acutely dissociated neurons from the rat ventromedial hypothalamus by NS 1619; Br. J. Pharmacol. 113 659
- Ningaraj et al. (2002), Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels; J. Pharmacol. Exp. Ther. 301 838
- Ningaraj et al. (2009), Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model; Cancer Biol. Ther. 8 1924
- Han et al. (2008), The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells; Biochem. Biophys. Res. Commun. 375 205
- Dai et al. (2017), Preconditioning with the BKCa channel activator NS-1619 prevents ischemia-reperfusion-induced inflammation and mucosal barrier dysfunction: roles for ROS and heme oxygenase-1; Am. J. Physiol. Heart Circ. Physiol. 313 H988
- Gao et al. (2022), NS1619 Alleviate Brain-Derived Extracellular Vesicle-Induced Brain Injury by Regulating BKCa Channel and Nrf2/HO-1/NK-kB Pathway; Oxid. Med. Cell Longev. 2022 2257427
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