NSC47924 | PHLP phosphatase inhibitor / Laminin inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $200.00 |
NSC47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM (IC50=19.35 μM) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3
References/Citations:
1) Sierecki et al. (2010), Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase PHLPP by chemical and virtual screening; J. Med. Chem., 53 6899
2) Pesapane et al. (2015), Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion; Oncotarget, 6 18116
3) Samataro et al. (2016), The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LA cell surface localization and interaction with the cellular prion protein; Sci. Rep., 6 24457
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NSC47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM (IC50=19.35 μM) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3
References/Citations:
1) Sierecki et al. (2010), Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase PHLPP by chemical and virtual screening; J. Med. Chem., 53 6899
2) Pesapane et al. (2015), Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion; Oncotarget, 6 18116
3) Samataro et al. (2016), The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LA cell surface localization and interaction with the cellular prion protein; Sci. Rep., 6 24457
Related products
-
Ko-143 | BCRP inhibitor
From $110.00CAS:461054-93-3Catalog Number:10-1074Activity:BCRP inhibitorChemical Name:(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido [3,4-b]indole-3-propanoic acid 1,1-dimethylethyl esterMolecular Weight:469.59Molecular Formula:C26H35N3O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Cantharidin | Phosphatase PP2A inhibitor
From $40.00CAS:56-25-7Catalog Number:10-1013Activity:Phosphatase PP2A inhibitorChemical Name:3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dioneMolecular Weight:196.2Molecular Formula:C10H12O4Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.Shipping Code:RT -
MK-571 | Cys LT1 antagonist
From $60.00CAS:115104-28-4Catalog Number:10-1039Activity:Cys LT1 antagonistAlternate Names:L-660711Chemical Name:5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acidMolecular Weight:515.09Molecular Formula:C26H27ClN2O3S2Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:95% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
