NSC632839 | DUB inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $260.00 |
NSC632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2 Cell permeable.
References/Citations:
1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235
2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NSC632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2 Cell permeable.
References/Citations:
1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235
2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035
Related products
-
Resveratrol | Antioxidant/SIRT1 activator
From $40.00CAS:501-36-0Catalog Number:10-1057Activity:Antioxidant/SIRT1 activatorAlternate Names:5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediolChemical Name:3,4′,5-Trihydroxy-trans-stilbeneMolecular Weight:228.25Molecular Formula:C14H12O3Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
BML-278 | SIRT1 activator
From $60.00CAS:120533-76-8Catalog Number:10-1063Activity:SIRT1 activatorChemical Name:N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridineMolecular Weight:391.47Molecular Formula:C24H25NO4Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:Off-white solidPurity:>98% TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
PR-619 | DUB inhibitor
From $50.00CAS:2645-32-1Catalog Number:10-1485Activity:DUB inhibitorAlternate Names:3,5-Dithiocyanatopyridine-2,6-diamineChemical Name:2,6-Diaminopyridine-3,5-bis(thiocyanate)Molecular Weight:223.28Molecular Formula:C7H5N5S2Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
