NSC95397 | CtBP inhibitor; Cdc25 phosphatase inhibitor

CAS:
93718-83-3
Catalog Number:
10-1565
Activity:
CtBP inhibitor; Cdc25 phosphatase inhibitor
Chemical Name:
2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Molecular Weight:
310.39
Molecular Formula:
C14H14O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$80.00
25 mg$300.00

NSC95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki  = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4

References/Citations:

1) Lazo et al. (2002), Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors; Mol. Pharmacol., 61 720
2) Melchheier et al. (2005), Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation; Biochem. Biophys. Res. Commun., 327 1016
3) Blevins et al. (2015), Small Molecule, NSC95397, inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression; J. Biomol. Screen., 20 663
4) Jemaa et al. (2016), Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397; Cell. Physiol. Biochem., 40 597

CAS:
93718-83-3
Catalog Number:
10-1565
Activity:
CtBP inhibitor; Cdc25 phosphatase inhibitor
Chemical Name:
2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Molecular Weight:
310.39
Molecular Formula:
C14H14O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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