NSC59984 | p53 activator

CAS:
803647-40-7
Catalog Number:
10-3148
Activity:
P53 activator
Chemical Name:
(E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
Molecular Weight:
265.27
Molecular Formula:
C12H15N3O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$60.00
25 mg$200.00

NSC59984 (803647-40-7) is a p53 activator.  Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells.1 Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.2,3

References/Citations:

1) Zhang et al. (2015), Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53; Cancer Res., 75 3842
2) Ferraiuolo et al. (2016), Oncogenic Intra-p53 Family Member Interactions in Human Cancers; Front. Oncol., 6 77
3) Hong et al. (2014), Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities; Curr. Drug Targets, 15 80

CAS:
803647-40-7
Catalog Number:
10-3148
Activity:
P53 activator
Chemical Name:
(E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
Molecular Weight:
265.27
Molecular Formula:
C12H15N3O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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