O151 | OGG1 inhibitor

O151 chemical structure

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5 mg$85.00
25 mg$340.00
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The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination.1 The BER pathway is now a validated target in cancer therapeutic development.2 O151 (2763063-26-7) is a selective and potent inhibitor of 8-oxoguanine DNA glycosylase-1 (OGG1) with IC50 of 0.6 μM.3

References/Citations:

  1. Hazra et al. (2007), Oxidative DNA damage repair in mammalian cells; DNA Repair (Amst) 6 470
  2. Curtin et al. (2012), DNA repair dysregulation from cancer driver to therapeutic target; Nat. Rev. Cancer 12 801
  3. Donley et al. (2015), Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1); ACS Chem. Biol. 10 2334
2763063-26-7, O-151, O151, O151 supplier, OGG1 inhibitor

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

The DNA base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of DNA damage induced by oxidation, alkylation, and deamination.1 The BER pathway is now a validated target in cancer therapeutic development.2 O151 (2763063-26-7) is a selective and potent inhibitor of 8-oxoguanine DNA glycosylase-1 (OGG1) with IC50 of 0.6 μM.3

References/Citations:

  1. Hazra et al. (2007), Oxidative DNA damage repair in mammalian cells; DNA Repair (Amst) 6 470
  2. Curtin et al. (2012), DNA repair dysregulation from cancer driver to therapeutic target; Nat. Rev. Cancer 12 801
  3. Donley et al. (2015), Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1); ACS Chem. Biol. 10 2334