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Obeticholic Acid | FXR agonist

Obeticholic acid (459789-99-2) is a novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis.1 Promotes adipocyte differentiation and regulates adipose cell function.2 Normalizes insulin sensitivity in a rabbit model of metabolic syndrome.3 A potentially new therapeutic agent for management of non-alcoholic fatty liver disease4 and NASH5. Displays therapeutic benefit in patients with primary biliary cirrhosis.6 Active in vivo.

References/Citations

1) Fiorucci et al. (2005), Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis; J. Pharmacol. Exp. Ther., 313 604
2) Rizzo et al. (2006), The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo; Mol. Pharmacol., 70 1164
3) Maneschi et al. (2013), FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS; J. Endocrinol., 218 215
4) Carr and Reid (2015), FXR agonists as therapeutic agents for non-alcoholic fatty liver disease; Curr. Atheroscler. Rep, 17 500
5) Jahn et al. (2016), Non-Alcoholic Steatohepatitis: From Pathophysiology to Novel Therapies; Dig. Dis., 34 356
6) Hirschfield et al. (2015), Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequade response to ursodeoxycholic acid; Gastroenterology, 148 751

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Catalog#  10-2838-0005

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
459789-99-2
Catalog Number:
10-2838
Activity:
FXR agonist
Chemical Name:
3α-7α-dihydroxy-6α-ethyl-5ß-cholan-24-oic acid
Alternate Names:
6-Ethylchenodeoxycholic acid; 6-ECDCA
Molecular Weight:
420.63
Molecular Formula:
C26H44O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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