ODQ | Soluble guanylyl cyclase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $30.00 | ||
| 25 mg | $84.00 |
ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2 ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1 ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5
References/Citations:
1) Garthwaite et al. (1995), Potent and Selective Inhibition of Nitric Oxide-sensitive Guanylyl Cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; Mol. Pharmacol. 48 184
2) Schrammel et al. (1996), Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase; Mol. Pharmacol. 50 1
3) Estevez et al. (1998), Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor; J. Neurosci. 18 3708
4) Vandecasteele et al. (1998), Role of the NO-cGMP in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes; J. Physiol. 506 653
5) Martins-Pinge et al. (1999), Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats; Hypertension 34 748
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2 ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1 ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5
References/Citations:
1) Garthwaite et al. (1995), Potent and Selective Inhibition of Nitric Oxide-sensitive Guanylyl Cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; Mol. Pharmacol. 48 184
2) Schrammel et al. (1996), Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase; Mol. Pharmacol. 50 1
3) Estevez et al. (1998), Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor; J. Neurosci. 18 3708
4) Vandecasteele et al. (1998), Role of the NO-cGMP in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes; J. Physiol. 506 653
5) Martins-Pinge et al. (1999), Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats; Hypertension 34 748
Related products
-
Vinpocetine | PDE1 inhibitor
From $30.00CAS:42971-09-5Catalog Number:10-1126Activity:PDE1 inhibitorChemical Name:(3α,16α)-Eburnamenine-14-carboxylic acid ethyl esterMolecular Weight:350.45Molecular Formula:C22H26N2O2Solubility:Soluble in DMSO (up to 5 mg/ml), in ethanol (up to 15 mg/ml) or in DMF (up to 3 mg/ml with warming)Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, Ethanol, or DMF may be stored at -20°C for up to 3 months.Shipping Code:RT -
8-pCPT-2-O-Me-cAMP-AM | Epac activator
$148.00CAS:1152197-23-3Catalog Number:10-2736Activity:Epac activatorChemical Name:8-(4-Chlorophenylthio)-2′-O-methyladenosine-3′,5′-cyclic monophosphate, acetoxymethyl esterMolecular Weight:557.91Molecular Formula:C20H21ClN5O8PSSolubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:solidPurity:97% by HPLCStorage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
ST034307 | Adenylate cyclase 1 inhibitor/analgesic activity
From $65.00CAS:133406-29-8Catalog Number:10-1620Activity:Adenylate cyclase 1 inhibitor/analgesic activityChemical Name:6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-oneMolecular Weight:297.95Molecular Formula:C10H4Cl4O2Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
