Size: | Price | Quantity | |
---|---|---|---|
10 mg | $50.00 | ||
50 mg | $200.00 |
Oleoylethanolamide (111-58-0) is an endogenous anandamide-like lipid acting as a PPARα agonist but does not bind to cannabinoid receptors.1 Biosynthesis via the action of NAPE-PLD on N-acylphosphatidylethanolamine.2 Agonist at GPR1193 and has been suggested to be its endogenous ligand4. Inhibits food intake in rodents.5 Extends the lifespan of C. elegans.6
References/Citations:
1) Lo Verme et al. (2005), Regulation of food intake by oleoylethanolamide; Cell Mol. Life Sci. 62 708
2) Magotti et al. (2015), Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids; Structure 23 598
3) Overton et al. (2006), Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecules hypophagic agents; Cell Metab. 3 167
4) Brown (2007), Novel cannabinoid receptors; Br. J. Pharmacol. 152 567
5) Nielson et al. (2004), Food intake is inhibited by oral oleoylethanolamide; J. Lipid Res. 45 1027
6) Folick et al. (2015), Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans; Science 347 83
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Oleoylethanolamide (111-58-0) is an endogenous anandamide-like lipid acting as a PPARα agonist but does not bind to cannabinoid receptors.1 Biosynthesis via the action of NAPE-PLD on N-acylphosphatidylethanolamine.2 Agonist at GPR1193 and has been suggested to be its endogenous ligand4. Inhibits food intake in rodents.5 Extends the lifespan of C. elegans.6
References/Citations:
1) Lo Verme et al. (2005), Regulation of food intake by oleoylethanolamide; Cell Mol. Life Sci. 62 708
2) Magotti et al. (2015), Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids; Structure 23 598
3) Overton et al. (2006), Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecules hypophagic agents; Cell Metab. 3 167
4) Brown (2007), Novel cannabinoid receptors; Br. J. Pharmacol. 152 567
5) Nielson et al. (2004), Food intake is inhibited by oral oleoylethanolamide; J. Lipid Res. 45 1027
6) Folick et al. (2015), Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans; Science 347 83
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