Oleoylethanolamide | GPR119 agonist / stimulates lipolysis

CAS:
111-58-0
Catalog Number:
10-1475
Activity:
GPR119 agonist: Stimulates lipolysis
Chemical Name:
N-(2-Hydroxyethyl)-9Z-octadecenamide
Alternate Names:
OEA
Molecular Weight:
325.53
Molecular Formula:
C20H39NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$50.00
50 mg$200.00

Oleoylethanolamide (111-58-0) is an endogenous anandamide-like lipid acting as a PPARα agonist but does not bind to cannabinoid receptors.1 Biosynthesis via the action of NAPE-PLD on N-acylphosphatidylethanolamine.2 Agonist at GPR1193 and has been suggested to be its endogenous ligand4. Inhibits food intake in rodents.5 Extends the lifespan of C. elegans.6

References/Citations:

1) Lo Verme et al. (2005), Regulation of food intake by oleoylethanolamide; Cell Mol. Life Sci. 62 708
2) Magotti et al. (2015), Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids; Structure 23 598
3) Overton et al. (2006), Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecules hypophagic agents; Cell Metab. 3 167
4) Brown (2007), Novel cannabinoid receptors; Br. J. Pharmacol. 152 567
5) Nielson et al. (2004), Food intake is inhibited by oral oleoylethanolamide; J. Lipid Res. 45 1027
6) Folick et al. (2015), Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans; Science 347 83

CAS:
111-58-0
Catalog Number:
10-1475
Activity:
GPR119 agonist: Stimulates lipolysis
Chemical Name:
N-(2-Hydroxyethyl)-9Z-octadecenamide
Alternate Names:
OEA
Molecular Weight:
325.53
Molecular Formula:
C20H39NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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