Oligomycin A | Mitochondrial ATPase inhibitor
CAS:
579-13-5
Catalog Number:
10-5368
Activity:
Mitochondrial ATPase inhibitor
Source:
Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11
Solubility:
Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $54.00 | ||
| 5 mg | $132.00 |
Oligomycin A (OA) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Evokes maximum thermogenic response from brown adipocytes upon co-treatment with norepinephrine.4 A glycolytic inhibitor (2-deoxyglucose) enhances the antiproliferative activity of OA in MCF-7 cells.5
References/Citations:
- Antoniel et al. (2014), The oligomycin-sensitivity conferring protein of mitochondrial ATP synthase: emerging new roles in mitochondrial pathophysiology; J. Mol. Sci., 15 7513
- DeVorkin et al. (2014), The Drosophilia effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB; J. Cell Biol., 205 477
- Serrill et al. (2015), Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A; Biochem. Toxicol., 93 251
- Meng et al. (2022), A sensitive mitochondrial thermometry 2.0 and the availability of thermogenic capacity of brown adipocyte; Front. Physiol., 13 977431
- Scherbakov et al. (2021), Glucose starvation greatly enhances antiproliferative and antiestrogenic potency of oligomycin A in MCF-7 breast cancer cells; Biochemie, 186 51
CAS:
579-13-5
Catalog Number:
10-5368
Activity:
Mitochondrial ATPase inhibitor
Source:
Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11
Solubility:
Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Oligomycin A (OA) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Evokes maximum thermogenic response from brown adipocytes upon co-treatment with norepinephrine.4 A glycolytic inhibitor (2-deoxyglucose) enhances the antiproliferative activity of OA in MCF-7 cells.5
References/Citations:
- Antoniel et al. (2014), The oligomycin-sensitivity conferring protein of mitochondrial ATP synthase: emerging new roles in mitochondrial pathophysiology; J. Mol. Sci., 15 7513
- DeVorkin et al. (2014), The Drosophilia effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB; J. Cell Biol., 205 477
- Serrill et al. (2015), Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A; Biochem. Toxicol., 93 251
- Meng et al. (2022), A sensitive mitochondrial thermometry 2.0 and the availability of thermogenic capacity of brown adipocyte; Front. Physiol., 13 977431
- Scherbakov et al. (2021), Glucose starvation greatly enhances antiproliferative and antiestrogenic potency of oligomycin A in MCF-7 breast cancer cells; Biochemie, 186 51
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