Omeprazole | Proton pump inhibitor / Antiviral
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 50 mg | $38.00 | ||
| 500 mg | $98.00 |
Omeprazole (73590-58-6) is a H+,K+-ATPase inhibitor (IC50 = 5.8 μM). Clinically useful antisecretory and antiulcer agent.1 Potent inhibitor of CYP2C19 (Ki=3.1 mM).2 Inhibits swelling-dependent chloride channels.3 Facilitates oral bioavailability of bioactive peptides such as oxytocin by raising stomach pH.4 Displays broad spectrum antiviral activity.5 Enhances efficacy of remdesivir (10-fold).6
References/Citations:
1) Satoh et al. (1989), Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats; J. Pharmacol. Exp. Ther., 248 806
2) Kuzin et al. (2018), Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine; Clin. Pharmacokinet, 57 729
3) Schmarda et al. (2000) The gastric H,K-ATPase blocker Iansoprazole is an inhibitor of chloride channels; Br. J. Pharmacol., 129 598
4) Maejima et al. (2020), Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake; Peptides, 128 170312
5) Wantanabe et al. (2020), Selective Targeting of Virus Replication by Proton Pump Inhibitors; Sci. Rep., 10 4003
6) Bojkova et al. (2020), SARS-CoV2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles; bioRxiv, epub ahead of print DOI: 10.1101/2020.04.03.024257
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Omeprazole (73590-58-6) is a H+,K+-ATPase inhibitor (IC50 = 5.8 μM). Clinically useful antisecretory and antiulcer agent.1 Potent inhibitor of CYP2C19 (Ki=3.1 mM).2 Inhibits swelling-dependent chloride channels.3 Facilitates oral bioavailability of bioactive peptides such as oxytocin by raising stomach pH.4 Displays broad spectrum antiviral activity.5 Enhances efficacy of remdesivir (10-fold).6
References/Citations:
1) Satoh et al. (1989), Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats; J. Pharmacol. Exp. Ther., 248 806
2) Kuzin et al. (2018), Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine; Clin. Pharmacokinet, 57 729
3) Schmarda et al. (2000) The gastric H,K-ATPase blocker Iansoprazole is an inhibitor of chloride channels; Br. J. Pharmacol., 129 598
4) Maejima et al. (2020), Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake; Peptides, 128 170312
5) Wantanabe et al. (2020), Selective Targeting of Virus Replication by Proton Pump Inhibitors; Sci. Rep., 10 4003
6) Bojkova et al. (2020), SARS-CoV2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles; bioRxiv, epub ahead of print DOI: 10.1101/2020.04.03.024257
Related products
-
GRL-0496 | SARS-CoV 3CLpro inhibitor
From $60.00CAS:1087243-14-8Catalog Number:10-4960Activity:SARS-CoV 3CLpro inhibitorChemical Name:1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl esterMolecular Weight:272.69Molecular Formula:C14H9ClN2O2Solubility:Soluble in DMSO (>30 mg/mL) and ethanol (>25 mg/mL)Physical Properties:White solidPurity:>98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
GRL-0617 | Potent SARS-CoV PLpro inhibitor
From $75.00CAS:1093070-16-6Catalog Number:10-4965Activity:Potent SARS-CoV PLpro inhibitorChemical Name:5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamideMolecular Weight:304.39Molecular Formula:C20H20N2OSolubility:Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)Physical Properties:Beige solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20° (des.)Stability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
N4-Hydroxycytidine | Novel antiviral
From $70.00CAS:3258-02-4Catalog Number:10-3970Activity:Novel antiviralChemical Name:1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-oneAlternate Name:beta-D-N4-hydroxycytidineMolecular Weight:259.22Molecular Formula:C9H13N3O6Solubility:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming).Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
