ONO-RS-082 | Phospholipase A2 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $55.00 | ||
| 100 mg | $220.00 |
ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2 (PLA2), IC50=7 μM for guinea pig lung PLA2.1 Inhibits epinephrine-induced thromboxane production in platelets.1 Inhibition of PLA2 by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4 Prevents Xenopus oocyte maturation at stage V.5
References/Citations:
1) Banga et al. (1986), Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA 83 9197
2) De Figueiredo et al. (2001), Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem. 276 47361
3) Schmidt et al. (2010), A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic 11 1530
4) Bechler and Brown (2014), Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol. 28 0004
5) Islam et al. (2005), The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal. 17 507
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2 (PLA2), IC50=7 μM for guinea pig lung PLA2.1 Inhibits epinephrine-induced thromboxane production in platelets.1 Inhibition of PLA2 by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4 Prevents Xenopus oocyte maturation at stage V.5
References/Citations:
1) Banga et al. (1986), Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA 83 9197
2) De Figueiredo et al. (2001), Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem. 276 47361
3) Schmidt et al. (2010), A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic 11 1530
4) Bechler and Brown (2014), Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol. 28 0004
5) Islam et al. (2005), The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal. 17 507
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