Oridonin | Inflammasome inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $40.00 | ||
| 50 mg | $150.00 |
Oridonin (28957-04-2) is a potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models.1 Inhibits vascular inflammation in vivo.2 Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling.3 Inhibits migration, invasion and adhesion of melanoma cells.4 Induces apoptosis in osteosarcoma cells by multiple pathways.5
References/Citations:
1) He et al. (2018), Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity; Nat. Commun., 9 2550
2) Huang et al. (2018), Oridonin inhibits vascular inflammation by blocking NF-kB and MAPK activation; Eur. J. Pharmacol., 826 133
3) Sun et al. (2018), Oridonin inhibits aberrant AKT activation in breast cancer; Oncotarget, 9 23878
4) Li et al. (2018), Oridonin inhibits migration, invasion, adhesion and TGF-ß1-induced epithelial-mesenchymal transition of melanoma cells by inhibiting the activity of PI3K/Akt/GSK-3ß signaling pathway; Oncol. Lett., 15 1362
5) Lu et al. (2018), Oridonin exerts anticancer effect on osteosarcoma by activating PPARγ and inhibiting Nrf2 pathway; Cell Death Dis., 9 15
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Oridonin (28957-04-2) is a potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models.1 Inhibits vascular inflammation in vivo.2 Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling.3 Inhibits migration, invasion and adhesion of melanoma cells.4 Induces apoptosis in osteosarcoma cells by multiple pathways.5
References/Citations:
1) He et al. (2018), Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity; Nat. Commun., 9 2550
2) Huang et al. (2018), Oridonin inhibits vascular inflammation by blocking NF-kB and MAPK activation; Eur. J. Pharmacol., 826 133
3) Sun et al. (2018), Oridonin inhibits aberrant AKT activation in breast cancer; Oncotarget, 9 23878
4) Li et al. (2018), Oridonin inhibits migration, invasion, adhesion and TGF-ß1-induced epithelial-mesenchymal transition of melanoma cells by inhibiting the activity of PI3K/Akt/GSK-3ß signaling pathway; Oncol. Lett., 15 1362
5) Lu et al. (2018), Oridonin exerts anticancer effect on osteosarcoma by activating PPARγ and inhibiting Nrf2 pathway; Cell Death Dis., 9 15
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