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Orlistat | DAG Lipase-alpha inhibitor

Orlistat (96829-58-2) is a lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays antitumor activity3. Orlistat prevents fat absorption in the gut and is a clinically useful antiobesity agent4.

1) Bisogno et al. (2006), Development of the first potent and specific inhibitors of endocannabinoid biosynthesis; Biochim. Biophys. Acta, 1761 205
2) Hadvary et al. (1991), The lipase inhibitor tetrahydrolipstatin bind covalently to the putative active site serine of pancreatic lipase; J. Biol. Chem., 266 2021
3) Kridel et al. (2004), Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity; Cancer Res., 64 2070
4) Ballinger & Peikin (2002), Orlistat: it's current status as an anti-obesity drug; Eur. J. Pharmacol., 440 109

Focus Biomolecules cell signaling tech supplier, chemical structure Orlistat | DAG Lipase-alpha inhibitor | CAS 96829-58-2

Catalog#  10-2448

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Catalog Number:
DAG Lipase-α inhibitor
Alternate Names:
Ro18-0647, (-)-Tetrahydrolipstatin
Chemical Name:
N-Formyl-L-leucine (1S)-10[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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