Oxaprozin | NFkB inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $40.00 | ||
| 50 mg | $90.00 |
Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB pathway.2 The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 μmol/l), with consequent potent analgesic activity, and NF-κB activation in inflammatory cells (IC50 = 50 μmol/l).3
References/Citations:
1) Merck 14:6924
2) Ottonello et al. (2009), Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway; Br. .J. Pharmacol., 157 294
3) Dallegri et al. (2005), A review of the emerging profile of the anti-inflammatory drug oxaprozin; Expert Opin .Pharmacother., 6 777
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB pathway.2 The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 μmol/l), with consequent potent analgesic activity, and NF-κB activation in inflammatory cells (IC50 = 50 μmol/l).3
References/Citations:
1) Merck 14:6924
2) Ottonello et al. (2009), Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway; Br. .J. Pharmacol., 157 294
3) Dallegri et al. (2005), A review of the emerging profile of the anti-inflammatory drug oxaprozin; Expert Opin .Pharmacother., 6 777
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