Ozagrel HCl | Thromboxane synthase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $56.00 | ||
| 50 mg | $230.00 |
Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM).1 Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM).1 Inhibits platelet aggregation2 in vitro and arachidonate-induced arterial contraction in vivo. Ozagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4.
References/Citations:
1) Hiraku et al. (1986), Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046); Jpn. J. Pharmacol., 41 393
2) Naito et al. (1983), Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets; Eur. J. Pharmacol., 91 41
3) Edmonds and Leffer (1984), Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death; Life Sci., 35 1763
4) Tomishima et al. (2013), Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice; BMC Gastroenterol., 30 13
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM).1 Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM).1 Inhibits platelet aggregation2 in vitro and arachidonate-induced arterial contraction in vivo. Ozagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4.
References/Citations:
1) Hiraku et al. (1986), Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046); Jpn. J. Pharmacol., 41 393
2) Naito et al. (1983), Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets; Eur. J. Pharmacol., 91 41
3) Edmonds and Leffer (1984), Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death; Life Sci., 35 1763
4) Tomishima et al. (2013), Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice; BMC Gastroenterol., 30 13
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