P053 | Protein phosphatase 5 inhibitor

CAS:
 1022417-69-1
Catalog Number:
 10-4060
P053 chemical structure Focus Biomolecules

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5 mg$60.00
25 mg$210.00

P053 (1022417-69-1) is a selective inhibitor of protein phosphatase 5 (PP5) – IC50 = 706 nM.1  PP5 regulates signaling cascades that are responsible for tumor initiation, progression, and metastasis and is thus an interesting anticancer target.  P053 induced apoptosis in 786-O renal carcinoma cells.  Inhibition of PP5 by P053 prevents deactivation of the death effector protein FADD and activates the extrinsic apoptosis pathway complex II.

References/Citations:

  1. Ahanin et al. (2023), Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer; Cell Chem. Biol. 30 1223
CAS:
1022417-69-1
Catalog Number:
10-4060
Activity:
Protein phosphatase 5 inhibitor
Chemical Names:
3,5-Dimethyl-N-[4-(phenylmethyl)phenyl]-4-isoxazolesulfonamide
Molecular Weight:
342.41
Molecular Formula:

C18H18N2O3S

Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
Beige solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored under an inert atmosphere at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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