P505-15 | Highly selective Syk inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $250.00 |
P505-15 (1370261-97-4) is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5
References/Citations:
- Coffey et al. (2012), Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis; J. Pharmacol. Exp. Ther. 340 350
- Hoellenriegel et al. (2012), Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration; Leukemia 26 1576
- Spurgeon et al. (2013), The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia; J. Pharmacol. Exp. Ther. 344 378
- Torres-Hernandex et al. (2019), Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis; Oncogene 38 4512
- Rasool et al. (2024), Identification and structural characterization of small molecule inhibitors of PINK1; Sci. Rep. 14 7739
C19H23N9O·HCl
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
P505-15 (1370261-97-4) is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5
References/Citations:
- Coffey et al. (2012), Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis; J. Pharmacol. Exp. Ther. 340 350
- Hoellenriegel et al. (2012), Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration; Leukemia 26 1576
- Spurgeon et al. (2013), The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia; J. Pharmacol. Exp. Ther. 344 378
- Torres-Hernandex et al. (2019), Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis; Oncogene 38 4512
- Rasool et al. (2024), Identification and structural characterization of small molecule inhibitors of PINK1; Sci. Rep. 14 7739
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