P7C3-A20 | NAMPT activator/Proneurogenic agent
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $280.00 |
P7C3-A20 (1235481-90-9) is a neuroprotective and proneurogenic agent acting via NAMPT stimulation.1 Displays neuroprotective and promotes endogenous reparative functions after traumatic brain injury (TBI).2 Furthermore it repairs the blood-brain barrier, arrests chronic neurodegeneration and restores cognition after TBI in a mouse model.3 P7C3-A20 exerts neuroprotective effects in a hypoxic-ischemic encephalopathy model.4 Suppresses neuroinflammation and protects retinal ganglion cells from optic nerve crush in a rat model.5
References/Citations:
- LoCoco et al. (2017), Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy; Elife, 6 e29626
- Blaya et al. (2014), Neuroprotective efficacy of a proneurigenic compound after traumatic brain injury; Neurotrauma, 31 476
- Vázquez-Rosa et al. (2020), P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition; Proc. Natl. Acad. Sci. USA, 117 27667
- Bai et al. (2020), The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3ß Signaling; Neuroscience, 441 197
- Oku et al. (2017), P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush; Invest. Ophthamol. Vis. Sci., 58 4877
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
P7C3-A20 (1235481-90-9) is a neuroprotective and proneurogenic agent acting via NAMPT stimulation.1 Displays neuroprotective and promotes endogenous reparative functions after traumatic brain injury (TBI).2 Furthermore it repairs the blood-brain barrier, arrests chronic neurodegeneration and restores cognition after TBI in a mouse model.3 P7C3-A20 exerts neuroprotective effects in a hypoxic-ischemic encephalopathy model.4 Suppresses neuroinflammation and protects retinal ganglion cells from optic nerve crush in a rat model.5
References/Citations:
- LoCoco et al. (2017), Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy; Elife, 6 e29626
- Blaya et al. (2014), Neuroprotective efficacy of a proneurigenic compound after traumatic brain injury; Neurotrauma, 31 476
- Vázquez-Rosa et al. (2020), P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition; Proc. Natl. Acad. Sci. USA, 117 27667
- Bai et al. (2020), The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3ß Signaling; Neuroscience, 441 197
- Oku et al. (2017), P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush; Invest. Ophthamol. Vis. Sci., 58 4877
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