Patulin | Oxidative- and ER-stress inducer

CAS:
149-29-1
Catalog Number:
10-2097
Activity:
Oxidative- and ER-stress inducer
Chemical Name:
4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
Alternate Names:
Clavacin, Mycoin, Penicidin, Terinin, NSC8120
Molecular Weight:
154.12
Molecular Formula:
C7H6O4
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
1 mg$44.00
5 mg$158.00

Patulin (149-29-1) is a mycotoxin found in contaminated fruits.  Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to several organs including liver and kidney in laboratory animals.3 Triggers NRF2-mediated survival mechanisms in kidney cells.4 Induces apoptosis through a ROS-mediated ER stress pathway.5

References/Citations:

1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455
2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92
3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343
4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1
5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328

CAS:
149-29-1
Catalog Number:
10-2097
Activity:
Oxidative- and ER-stress inducer
Chemical Name:
4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
Alternate Names:
Clavacin, Mycoin, Penicidin, Terinin, NSC8120
Molecular Weight:
154.12
Molecular Formula:
C7H6O4
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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