Patulin | Oxidative- and ER-stress inducer
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $44.00 | ||
| 5 mg | $158.00 |
Patulin (149-29-1) is a mycotoxin found in contaminated fruits. Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to several organs including liver and kidney in laboratory animals.3 Triggers NRF2-mediated survival mechanisms in kidney cells.4 Induces apoptosis through a ROS-mediated ER stress pathway.5
References/Citations:
1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455
2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92
3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343
4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1
5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Patulin (149-29-1) is a mycotoxin found in contaminated fruits. Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to several organs including liver and kidney in laboratory animals.3 Triggers NRF2-mediated survival mechanisms in kidney cells.4 Induces apoptosis through a ROS-mediated ER stress pathway.5
References/Citations:
1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455
2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92
3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343
4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1
5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328
Related products
-
Pyocyanin | ROS generator
From $60.00CAS:85-66-5Catalog Number:10-1507Activity:ROS generatorAlternate Names:Pyocyanin, Sanasin, SanazinChemical Name:5-Methyl-1(5H)-phenazinoneMolecular Weight:210.23Molecular Formula:C13H10N2OSolubility:Soluble in DMSO (up to 15 mg/ml).Physical Properties:Dark blue solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.Shipping Code:RT -
Idebenone | Quinone antioxidant and free radical scavenger
From $70.00CAS:58186-27-9Catalog Number:10-1130Activity:Quinone antioxidant and free radical scavengerChemical Name:2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dioneMolecular Weight:338.44Molecular Formula:C19H30O5Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
DMPO | Spin trap
From $45.00CAS:3317-61-1Catalog Number:10-2299Activity:Spin trapChemical Name:5,5-Dimethyl-1-pyrroline N-oxideMolecular Weight:113.16Molecular Formula:C6H11NOSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Pale yellow oil or low melting point solidPurity:99% by HPLCStorage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Protect from exposure to light and moisture. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
