Pazopanib | Multi-receptor tyrosine kinase inhibitor

CAS:
 444731-52-6
Catalog Number:
 10-2158
Pazopanib chemical structure Focus Biomolecules

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10 mg$40.00
50 mg$120.00

Pazopanib (444731-52-6) inhibits multiple receptor tyrosine kinases including VEGFR1,2 and 3 (IC50s=10, 30, 47 nM respectively) and PDGFRα, β and c-Kit (IC50s=71, 84, 74 nM respectively) and others such as FGFR.1  The drug targets both the tumor and endothelial cells in a mouse xenograft model of human multiple myeloma.2 It reduces joint pain and inhibits cartilage degeneration in rodent osteoarthritis models.3 VEGF inhibitors such as pazopanib have potential for treatment of neovascular age-related macular degeneration.4 In clinical use for renal cell carcinoma.5

References/Citations:

  1. Kumar et al. (2007) Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity; Mol. Cancer Ther. 6 2012
  2. Podar et al. (2006) The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma; Proc. Natl. Acad. Sci. USA 103 19478
  3. Ma et al. (2023) Targeting Vascular Endothelial Growth Factor Receptors as a Therapeutic Strategy for Osteoarthritis and Associated Pain; Int. J. Biol. Sci. 19 675
  4. Rami-Baraka and Kaiser (2009) VEGF inhibitors for the treatment of neovascular age-related macular degeneration; Expert Opin. Investig. Drugs 18 637
  5. Comandone et al. (2021) Antiangiogenic Therapy in Clear Cell Renal Carcinoma (CCRC): Pharmacological Basis and Clinical Results; Cancers (Basel) 13 5896
CAS:
444731-52-6
Catalog Number:
10-2158
Activity:
Tyrosine kinase inhibitor
Chemical Names:
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
Alternate Name:
GSK-VEG10003; GW786034B
Molecular Weight:
437.52
Molecular Formula:

C21H23N7O2S

Solubility:
Soluble in DMSO (16 mg/ml)
Physical Properties:
White to off-white solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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