PCI-34051 | HDAC 8 inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $240.00 |
PCI-34051 (950762-95-5) is a potent and selective HDAC8 inhibitor (IC50=10 nM) with greater than 200-fold selectivity over HDACs 1, 2, 3, 6, 10.1 Unlike broad-spectrum HDAC inhibitors, it does not cause detectable histone or tubulin acetylation.1 Studies employing PCI-34051 showed that HDAC8 catalyzes the hydrolysis of long chain fatty acyl lysine.2 It is a very useful tool for exploring the role of HDAC8 in cellular function.3-6
References/Citations:
- Balasubramanian et al. (2008), A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas; Leukemia 22 1026
- Aramsangtienchai et al. (2016), HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine; ACS Chem. Biol. 11 2685
- Dasgupta et al. (2016), HDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression without Affecting Cohesion-dependent Transcription in MCF7 Cancer Cells; J. Biol. Chem. 291 12761
- Ha et al. (2016), Inhibition of Interleukin 1ß (IL-1ß) Expression by Anthrax Lethal Toxin (LeTx) is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages; J. Biol. Chem. 291 8745
- Fukuda et al. (2024), Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone; Int. J. Mol. Sci. 25 2540
- Mormino et al. (2024), Histone-deacetylase 8 drives the immune response and the growth of glioma; Glia 69 2682
C17H16N2O3
>98% (TLC)
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PCI-34051 (950762-95-5) is a potent and selective HDAC8 inhibitor (IC50=10 nM) with greater than 200-fold selectivity over HDACs 1, 2, 3, 6, 10.1 Unlike broad-spectrum HDAC inhibitors, it does not cause detectable histone or tubulin acetylation.1 Studies employing PCI-34051 showed that HDAC8 catalyzes the hydrolysis of long chain fatty acyl lysine.2 It is a very useful tool for exploring the role of HDAC8 in cellular function.3-6
References/Citations:
- Balasubramanian et al. (2008), A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas; Leukemia 22 1026
- Aramsangtienchai et al. (2016), HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine; ACS Chem. Biol. 11 2685
- Dasgupta et al. (2016), HDAC8 Inhibition Blocks SMC3 Deacetylation and Delays Cell Cycle Progression without Affecting Cohesion-dependent Transcription in MCF7 Cancer Cells; J. Biol. Chem. 291 12761
- Ha et al. (2016), Inhibition of Interleukin 1ß (IL-1ß) Expression by Anthrax Lethal Toxin (LeTx) is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages; J. Biol. Chem. 291 8745
- Fukuda et al. (2024), Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone; Int. J. Mol. Sci. 25 2540
- Mormino et al. (2024), Histone-deacetylase 8 drives the immune response and the growth of glioma; Glia 69 2682
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