PD 123319 ditrifluoroacetate | Angiotensin II type II antagonist
CAS:
136676-91-0
Catalog Number:
10-4959
Activity:
Angiotensin II AT2 antagonist
Chemical Names:
(6S)-1-[[4-(Dimethylamino)-3-methylphenylmethyl]-5-(2,2diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Molecular Weight:
736.66
Molecular Formula:
C31H32N4O3·2CF3CO2H
Solubility:
Soluble in DMSO (>25 mg/ml); Water (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $230.00 |
PD 123319 (136676-91-0) is a potent (IC50 = 34 nM) and selective non-peptide angiotensin II type 2 (AT2) antagonist.1 Ameliorated symptoms of 2,4-dinitrobenzenesulfonic-induced colitis in rats via inhibition of NF-kB activation.2 PD 123319 displayed protective effects in ischemia-reperfusion injury and oxidative damage in rat hearts.3
References/Citations:
- Blankley et al. (1991), Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype; J. Med. Chem. 34 3248
- Zizzo et al. (2020); PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2,4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility; Inflammopharmacology 28 187
- Kilic et al. (2019); Angiotensin II type 2 receptor blocker PD123319 had more beneficial effects than losartan on ischemia-reperfusion injury and oxidative damage in isolated rat hearts; Can. J. Physiol. Pharmacol. 97 1124
CAS:
136676-91-0
Catalog Number:
10-4959
Activity:
Angiotensin II AT2 antagonist
Chemical Names:
(6S)-1-[[4-(Dimethylamino)-3-methylphenylmethyl]-5-(2,2diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Molecular Weight:
736.66
Molecular Formula:
C31H32N4O3·2CF3CO2H
Solubility:
Soluble in DMSO (>25 mg/ml); Water (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PD 123319 (136676-91-0) is a potent (IC50 = 34 nM) and selective non-peptide angiotensin II type 2 (AT2) antagonist.1 Ameliorated symptoms of 2,4-dinitrobenzenesulfonic-induced colitis in rats via inhibition of NF-kB activation.2 PD 123319 displayed protective effects in ischemia-reperfusion injury and oxidative damage in rat hearts.3
References/Citations:
- Blankley et al. (1991), Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype; J. Med. Chem. 34 3248
- Zizzo et al. (2020); PD123319, angiotensin II type II receptor antagonist, inhibits oxidative stress and inflammation in 2,4-dinitrobenzene sulfonic acid-induced colitis in rat and ameliorates colonic contractility; Inflammopharmacology 28 187
- Kilic et al. (2019); Angiotensin II type 2 receptor blocker PD123319 had more beneficial effects than losartan on ischemia-reperfusion injury and oxidative damage in isolated rat hearts; Can. J. Physiol. Pharmacol. 97 1124
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