PD-150606 | Calpain Inhibitor

CAS:
179528-45-1
Catalog Number:
10-1515
Activity:
Calpain Inhibitor
Chemical Name:
(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Molecular Weight:
306.12
Molecular Formula:
C9H7IO2S
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$69.00
25 mg$276.00
This product is also available in the following library:

PD-150606 (179528-45-1) is a selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.1 PD-150606 displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death.2 Some protective effects may be due to inhibition of MMP activity.3

References/Citations:

1) Wang et al. (1996), An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective; Proc. Natl. Acad. Sci. USA, 93 6687
2) Waters et al. (1997), Calpains mediate calcium and chloride influx during the late phase of cell injury; J. Pharmacol. Exp. Therap., 283 1177
3) Ali et al. (2012), Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity; Biochem. Biophys. Res. Commun., 423 1

CAS:
179528-45-1
Catalog Number:
10-1515
Activity:
Calpain Inhibitor
Chemical Name:
(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Molecular Weight:
306.12
Molecular Formula:
C9H7IO2S
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!