PD 325901 MEK inhibitor

PD 325901 (391210-10-9) is a selective non-ATP competitive MEK inhibitor (IC₅₀ = 0.33 nM).¹ Inhibits growth and/or proliferation of a variety of cancer cells.² Enhances self-renewal of embryonic stem cells.³ In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.⁴ In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.⁵

References/Citations
1) Sebolt-Leopold et al. (2004), The biological profile of PD0325901: A second generation analog of CI-1040 with improved pharmaceutical potential; Proc. Amer. Assoc. Cancer Res., 45 925
2) Ciuffreda et al. (2009), Growth-inhibitor and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations; Neoplasia, 11 720
3) Ai et al. (2016), Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901; Stem Cells Int., 2016 1792573
4) Li et al. (2016), MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells; Oncotarget, 7 39730
5) Li et al. (2009), Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors; Cell Stem Cell, 4 16