PD 325901 (391210-10-9) is a selective Non-ATP-competitive MEK inhibitor (IC50 = 0.33nM)1. Inhibits growth and/or proliferation in a variety of cancer cells.2 PD 325901 enhances self-renewal of embryonic stem cells.
1) Sebolt-Leopold et al. (2004), The biological profile of PD0325901: A second generation analog of CI-1040 with improved pharmaceutical potential; Proc. Amer. Assoc. Cancer Res., 45 925
2) Ciuffreda et al. (2009), Growth-inhibitoir and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations; Neoplasia, 11 720