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Product Details
PD 325901 MEK inhibitor
PD 325901 (391210-10-9) is a selective Non-ATP-competitive MEK inhibitor (IC50 = 0.33nM)1. Inhibits growth and/or proliferation in a variety of cancer cells.2 PD 325901 enhances self-renewal of embryonic stem cells.
References/Citations
1) Sebolt-Leopold et al. (2004), The biological profile of PD0325901: A second generation analog of CI-1040 with improved pharmaceutical potential; Proc. Amer. Assoc. Cancer Res., 45 925
2) Ciuffreda et al. (2009), Growth-inhibitoir and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations; Neoplasia, 11 720
Catalog# 10-2161
$50.00
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
CAS:
391210-10-9
Catalog Number:
10-2161
Activity:
MEK inhibitor
Chemical Name:
N-[(2R(-))-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Molecular Weight:
482.2
Molecular Formula:
C16H14F3IN2O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.
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